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Histological evaluation and E-cadherin and β-catenin expression in kidney of dogs submitted to renal ischemia and reperfusion after chlorpromazine administration Arq. Bras. Med. Vet. Zootec.
Menezes,L.B.; Fioravanti,M.C.S.; Oliveira,F.A.; Silva,M.S.B.; Franco,L.G.; Sales,T.P.; Andrascko,M.M.; Guimarães,L.L.B.; Miguel,M.P.; Araújo,E.G..
ABSTRACT Renal ischemia can be associated with some urological procedures, such as renovascular surgery or kidney transplantation, that are often followed by acute renal failure. The aim of this study was to verify the E-cadherin and β-catenin localization in canine kidney in different times of renal ischemia and reperfusion after chlorpromazine application. Twelve dogs were randomly distributed equally into two groups. GroupA with ischemia and reperfusion without chlorpromazine and groupB with ischemia and reperfusion treated by chlorpromazine. GroupB received intravenous chlorpromazine, 15 min before the artery obstruction, which lasted 1 hour. After this period, the clamps in the renal arteries were released and the organ remained in reperfusion for 2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute renal failure; Adherens junctions; Cell adhesion; Kidney tubular necrosis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000501206
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